Frank Kozielski: search on Z-Library

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1

Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

Talapatra, Sandeep K., Tham, Chuin Lean, Guglielmi, Paolo, Cirilli, Roberto, Chandrasekaran, Balakumar, Karpoormath, Rajshekhar, Carradori, Simone, Kozielski, Frank

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.83 MB

english, 2018

2

Kinesins and cancer

Rath, Oliver, Kozielski, Frank

Journal:

Nature Reviews Cancer

Year:

2012

Language:

english

File:

PDF, 545 KB

english, 2012

3

Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5

Khathi, Samukelisiwe Pretty, Chandrasekaran, Balakumar, Karunanidhi, Sivanandhan, Tham, Chuin Lean, Kozielski, Frank, Sayyad, Nisar, Karpoormath, Rajshekhar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 2.22 MB

english, 2018

4

The Marine Natural Product Adociasulfate-2 as a Tool To Identify the MT-Binding Region of Kinesins †

Brier, Sébastien, Carletti, Eugénie, DeBonis, Salvatore, Hewat, Elisabeth, Lemaire, David, Kozielski, Frank

Journal:

Year:

2006

Language:

english

File:

PDF, 350 KB

english, 2006

5

New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations

Labrière, Christophe, Talapatra, Sandeep K., Thoret, Sylviane, Bougeret, Cécile, Kozielski, Frank, Guillou, Catherine

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.95 MB

english, 2016

6

The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping

Chatrin, Chatrin, Talapatra, Sandeep K., Canard, Bruno, Kozielski, Frank

Journal:

Year:

2018

Language:

english

File:

PDF, 1.70 MB

english, 2018

7

Structure−Activity Relationship and Multidrug Resistance Study of New S -trityl- l -Cysteine Derivatives As Inhibitors of Eg5

Kaan, Hung Yi Kristal, Weiss, Johanna, Menger, Dominik, Ulaganathan, Venkatasubramanian, Tkocz, Katarzyna, Laggner, Christian, Popowycz, Florence, Joseph, Benoît, Kozielski, Frank

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.43 MB

english, 2011

8

Indolobenzazepin-7-ones and 6-, 8-, and 9-Membered Ring Derivatives as Tubulin Polymerization Inhibitors: Synthesis and Structure−Activity Relationship Studies

Putey, Aurélien, Popowycz, Florence, Do, Quoc-Tuan, Bernard, Philippe, Talapatra, Sandeep K., Kozielski, Frank, Galmarini, Carlos M., Joseph, Benoît

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 3.25 MB

english, 2009

9

Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein

Ulaganathan, Venkatasubramanian, Talapatra, Sandeep K., Rath, Oliver, Pannifer, Andrew, Hackney, David D., Kozielski, Frank

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 1.70 MB

english, 2013

10

Kinesins and Cancer ||

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 8.57 MB

english, 2015

11

Kinesins and Cancer || Down-Regulating CENP-E Activity: For Better or for Worse

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 381 KB

english, 2015

12

Kinesins and Cancer || Chromokinesins in Genome Maintenance and Cancer

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 336 KB

english, 2015

13

Corrigendum to “Design and synthesis of novel thiadiazole-thiazolone hybrids as potential inhibitors of the human mitotic kinesin Eg5 [Bioorg Med Chem Lett 28 (17) (2018) 2930–2938]”

Khathi, Samukelisiwe Pretty, Chandrasekaran, Balakumar, Karunanidhi, Sivanandhan, Tham, Chuin Lean, Kozielski, Frank, Sayyad, Nisar, Karpoormath, Rajshekhar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 493 KB

english, 2018

14

Rhombohedral PLZT piezoelectric microfibers: a combined Raman and X-ray diffraction study

Kozielski, Lucjan, Buixaderas, Elena, Clemens, Frank

Journal:

Phase Transitions

Year:

2014

Language:

english

File:

PDF, 930 KB

english, 2014

15

Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism

Talapatra, Sandeep K., Anthony, Nahoum G., Mackay, Simon P., Kozielski, Frank

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 629 KB

english, 2013

16

Essential Kinesins: Characterization of Caenorhabditis elegans KLP-15 †

Robin, Gautier, DeBonis, Salvatore, Dornier, Aurélie, Cappello, Giovanni, Ebel, Christine, Wade, Richard H., Thierry-Mieg, Danielle, Kozielski, Frank

Journal:

Year:

2005

Language:

english

File:

PDF, 797 KB

english, 2005

17

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-l-cysteine in tumor derived cell lines

Sergey Tcherniuk, Robert van Lis, Frank Kozielski, Dimitrios A. Skoufias

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 2.39 MB

english, 2010

18

Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives

Daniel B. Nichols, Guy Fournet, K.R. Gurukumar, Amartya Basu, Jin-Ching Lee, Naoya Sakamoto, Frank Kozielski, Ira Musmuca, Benoît Joseph, Rino Ragno, Neerja Kaushik-Basu

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

19

Kinesins and Cancer || The Kinesin Superfamily

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

20

Ligand and structure based in silico studies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents

Balakumar, Chandrasekaran, Ramesh, Muthusamy, Tham, Chuin Lean, Khathi, Samukelisiwe Pretty, Kozielski, Frank, Srinivasulu, Cherukupalli, Hampannavar, Girish A., Sayyad, Nisar, Soliman, Mahmoud E., Ka

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2017

Language:

english

File:

PDF, 4.20 MB

english, 2017

21

Is the fate of clinical candidate Arry-520 already sealed? Predicting resistance in Eg5-inhibitor complexes

Indorato, Rose-Laure, Talapatra, Sandeep K., Lin, Fangzhu, Haider, Shozeb, Mackay, Simon P., Kozielski, Frank, Skoufias, Dimitrios A.

Journal:

Molecular Cancer Therapeutics

Year:

2019

Language:

english

File:

PDF, 14.70 MB

english, 2019

22

Crystallization and Preliminary X-Ray Analysis of the Single-Headed and Double-Headed Motor Protein Kinesin

Frank Kozielski, Ernst Schönbrunn, Stefan Sack, Jens Müller, Scott T. Brady, Eckhard Mandelkow

Journal:

Journal of Structural Biology

Year:

1997

Language:

english

File:

PDF, 583 KB

english, 1997

23

Light-Intensity-Induced Characterization of Elastic Constants and d33 Piezoelectric Coefficient of PLZT Single Fiber Based Transducers

Kozielski, Lucjan, Erhart, Jiri, Clemens, Frank

Journal:

Year:

2013

Language:

english

File:

PDF, 854 KB

english, 2013

24

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases

Riccio, Federica, Talapatra, Sandeep K., Oxenford, Sally, Angell, Richard, Mazzon, Michela, Kozielski, Frank

Journal:

Year:

2019

File:

PDF, 1.86 MB

2019

25

Receptor–Ligand Interaction-Based Virtual Screening for Novel Eg5/Kinesin Spindle Protein Inhibitors

Nagarajan, Shanthi, Skoufias, Dimitrios A., Kozielski, Frank, Pae, Ae Nim

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 711 KB

english, 2012

26

Kinesins and Cancer || Mechanisms of Action of Eg5 Inhibitors

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 463 KB

english, 2015

27

Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol

Kaan, Hung Yi Kristal, Ulaganathan, Venkatasubramanian, Rath, Oliver, Prokopcová, Hana, Dallinger, Doris, Kappe, C. Oliver, Kozielski, Frank

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.18 MB

english, 2010

28

STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity

Indorato, Rose-Laure, DeBonis, Salvatore, Kozielski, Frank, Garcia-Saez, Isabel, Skoufias, Dimitrios A.

Journal:

Biochemical Pharmacology

Year:

2013

Language:

english

File:

PDF, 2.44 MB

english, 2013

29

Identification of the Protein Binding Region of S -Trityl- l -cysteine, a New Potent Inhibitor of the Mitotic Kinesin Eg5 †

Brier, Sébastien, Lemaire, David, DeBonis, Salvatore, Forest, Eric, Kozielski, Frank

Journal:

Year:

2004

Language:

english

File:

PDF, 348 KB

english, 2004

30

Kinesins and Cancer || Non-motor Spindle Proteins as Cancer Chemotherapy Targets

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

31

Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor

Dr. Sergey Tcherniuk, Dr. Dimitrios A. Skoufias, Dr. Christophe Labriere, Dr. Oliver Rath, Dr. Françoise Gueritte, Dr. Catherine Guillou, Prof. Dr. Frank Kozielski

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 777 KB

english, 2010

32

Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives

Florence Popowycz, Cédric Schneider, Salvatore DeBonis, Dimitrios A. Skoufias, Frank Kozielski, Carlos M. Galmarini, Benoît Joseph

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 586 KB

english, 2009

33

Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine

Murad N. Abualhasan, James A.D. Good, Kitiyaporn Wittayanarakul, Nahoum G. Anthony, Giacomo Berretta, Oliver Rath, Frank Kozielski, Oliver B. Sutcliffe, Simon P. Mackay

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 860 KB

english, 2012

34

Molecular Dissection of the Inhibitor Binding Pocket of Mitotic Kinesin Eg5 Reveals Mutants that Confer Resistance to Antimitotic Agents

Sébastien Brier, David Lemaire, Salvatore DeBonis, Eric Forest, Frank Kozielski

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.09 MB

english, 2006

35

Kinesins and Cancer || Kif14: A Clinically Relevant Kinesin and Potential Target for Cancer Therapy

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 458 KB

english, 2015

36

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5

Frank Kozielski, Dimitrios A. Skoufias, Rose-Laure Indorato, Yasmina Saoudi, Peter R. Jungblut, Hanne K. Hustoft, Margarita Strozynski, Bernd Thiede

Journal:

Year:

2008

Language:

english

File:

PDF, 483 KB

english, 2008

37

Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity

Wang, Fang, Good, James A. D., Rath, Oliver, Kaan, Hung Yi Kristal, Sutcliffe, Oliver B., Mackay, Simon P., Kozielski, Frank

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.18 MB

english, 2012

38

ChemInform Abstract: Synthesis of 5-Acyl-3,4-dihydropyrimidine-2-thiones via Solvent-Free, Solution-Phase and Solid-Phase Biginelli Procedures.

Horacio Comas, David-Alexandre Buisson, Romain Najman, Frank Kozielski, Bernard Rousseau, Roman Lopez

Journal:

Year:

2009

File:

PDF, 31 KB

2009

39

A model of the microtubule–kinesin complex based on electron cryomicroscopy and X-ray crystallography

Frank Kozielski, Isabelle Arnal, Richard H. Wade

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 547 KB

english, 1998

40

Motor-Dependent Microtubule Disassembly Driven by Tubulin Tyrosination

Leticia Peris, Michael Wagenbach, Laurence Lafanechère, Jacques Brocard, Ayana T. Moore, Frank Kozielski, Didier Job, Linda Wordeman and Annie Andrieux

Journal:

The Journal of Cell Biology

Year:

2009

Language:

english

File:

PDF, 2.20 MB

english, 2009

41

Kinesins and Cancer || Kif15: A Useful Target for Anti-cancer Therapy?

Kozielski, FSB, Frank

Year:

2015

Language:

english

File:

PDF, 277 KB

english, 2015

42

Proteome analysis of microtubule-associated proteins and their interacting partners from mammalian brain

Frank Kozielski, Tahira Riaz, Salvatore DeBonis, Christian J. Koehler, Mario Kroening, Isabel Panse, Margarita Strozynski, Ian M. Donaldson, Bernd Thiede

Journal:

Year:

2011

Language:

english

File:

PDF, 1.35 MB

english, 2011

43

Structural Variations in Protein Superfamilies: Actin and Tubulin

Richard H. Wade, Isabel Garcia-Saez, Frank Kozielski

Journal:

Molecular Biotechnology

Year:

2009

Language:

english

File:

PDF, 442 KB

english, 2009

44

Structure–Activity Relationship of S -Trityl- l -Cysteine Analogues as Inhibitors of the Human Mitotic Kinesin Eg5

DeBonis, Salvatore, Skoufias, Dimitrios A., Indorato, Rose-Laure, Liger, François, Marquet, Bernard, Laggner, Christian, Joseph, Benoît, Kozielski, Frank

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 721 KB

english, 2008

45

An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

Kaan, Hung Yi Kristal, Ulaganathan, Venkatasubramanian, Hackney, David D., Kozielski, Frank

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 790 KB

english, 2010

46

Synthesis of 5-Acyl-3,4-dihydropyrimidine-2-thiones via Solvent-Free, Solution-Phase and Solid-Phase Biginelli Procedures

Comas, Horacio, Buisson, David-Alexandre, Najman, Romain, Kozielski, Frank, Rousseau, Bernard, Lopez, Roman

Journal:

Year:

2009

Language:

english

File:

PDF, 89 KB

english, 2009

47

Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

Rogstam, Annika, Nyblom, Maria, Christensen, Signe, Sele, Celeste, Talibov, Vladimir O., Lindvall, Therese, Rasmussen, Anna Andersson, AndrÃ©, Ingemar, Fisher, ZoÃ«, Knecht, Wolfgang, Kozielski, Frank

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 2.33 MB

2020

48

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Klejnot, Marta, Gabrielsen, Mads, Cameron, Jenifer, Mleczak, Andrzej, Talapatra, Sandeep K., Kozielski, Frank, Pannifer, Andrew, Olson, Michael F.

Journal:

Acta Crystallographica Section D Biological Crystallography

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

49

Modified peptide inhibitors of the Keap1-Nrf2 protein-protein interaction incorporating unnatural amino acids

Georgakopoulos, Nikolaos D, Talapatra, Sandeep K, Gatliff, Jemma, Kozielski, Frank, Wells, Geoff

Journal:

Year:

2018

Language:

english

File:

PDF, 1.87 MB

english, 2018

50

Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor

Dr. Sergey Tcherniuk, Dr. Dimitrios A. Skoufias, Dr. Christophe Labriere, Dr. Oliver Rath, Dr. Françoise Gueritte, Dr. Catherine Guillou, Prof. Dr. Frank Kozielski

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 796 KB

english, 2010

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